Protective effect of carbon monoxide in transplantation

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Protective effect of carbon monoxide in transplantation

During the last decades due to the development of new immunosuppressive agents and improvements in organ preservation methods, surgical techniques, and postoperative care, organ transplantation has become an ultimate therapeutic option for irreversible organ failure. Early graft survival has significantly improved; however, the long-term outcome remains unsatisfactory. Multiple factors, both im...

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Histopathological study of erythropoietin protective effect on carbon monoxide-induced cardiotoxicity in rat

Objective(s): Cardiotoxicity is one of the major consequences in carbon monoxide poisoning. Following our previous work, in this study we aimed to define the myocardium changes induced by carbon monoxide (CO) intoxication and evaluate erythropoietin (EPO) effect on CO cardiotoxicity in rat. Materials and Methods:  Severe carbon monoxide toxicity induced by 3000 ppm CO in Wistar rat.  EPO was ad...

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Histopathological study of erythropoietin protective effect on carbon monoxide-induced cardiotoxicity in rat

Objectives Cardiotoxicity is one of the major consequences in carbon monoxide poisoning. Following our previous work, in this study we aimed to define the myocardium changes induced by carbon monoxide (CO) intoxication and evaluate erythropoietin (EPO) effect on CO cardiotoxicity in rat. Materials and Methods Severe carbon monoxide toxicity induced by 3000 ppm CO in Wistar rat. EPO was admini...

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Protective Effect of Edaravone against Carbon Monoxide Induced Apoptosis in Rat Primary Cultured Astrocytes

Objective. To observe the protective effect of edaravone (Eda) on astrocytes after prolonged exposure to carbon monoxide (CO) and further to investigate the potential mechanisms of Eda against CO-induced apoptosis. Methods. The rat primary cultured astrocytes were cultured in vitro and exposed to 1% CO for 24 h after being cultured with different concentrations of Eda. MTT assay was used to det...

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Protective effect of carbon monoxide-releasing compounds in ischemia-induced acute renal failure.

Heme oxygenase (HO) induction has been demonstrated to be beneficial in limiting the extent of cellular damage after ischemia-induced acute renal failure (ARF). Because increased HO activity is associated with the production of carbon monoxide (CO) as well as the potent antioxidant bilirubin, it is unclear which of the two is of greater importance in the protective effects of HO induction. The ...

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ژورنال

عنوان ژورنال: Journal of Cellular and Molecular Medicine

سال: 2006

ISSN: 1582-1838,1582-4934

DOI: 10.2755/jcmm010.003.16